CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
Jonathan Richard, Gérémy Sannier, Li Zhu, Jérémie Prévost, Lorie Marchitto, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Hongil Kim, Yaping Sun, Debashree Chatterjee, Halima Medjahed, Catherine Bourassa, Gloria-Gabrielle Ortega-Delgado, Mathieu Dubé, Frank Kirchhoff, , Andrés Finzi
The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.
mBio · Oct 7, 2024Peer-reviewedMicrobiology