Author

Thomas James O’Brien

MRC London Institute of Medical SciencesORCID 0000-0002-5529-331XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Animal Behavior & Cognition· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

André EX BrowniD· 2 shared Abdolmajid Omrani· 1 shared Abdullah AlamriiD· 1 shared Amal Mohammed AlhashemiD· 1 shared Anna WredenbergiD· 1 shared Annalaura TorellaiD· 1 shared Antonio VitobelloiD· 1 shared Ayat H. Al SafariD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersAnimal Behavior & Cognition

André EX BrownORCID

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2 papers

Recent·Most cited

High-throughput behavioural phenotyping of 25 C. elegans disease models including patient-specific mutations

Thomas James O’Brien, Emma Lara Navarro, Consuelo Barroso, Lara A. Menzies, Enrique Martínez-Pérez, David Carling, André EX Brown

This paper uses automated behavioural tracking in C. elegans to phenotype 25 disease models, revealing both strong and subtle mutant effects that could aid drug repurposing.

BMC Biology · Sep 26, 2025Peer-reviewedAnimal Behavior & Cognition

Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy and periventricular calcifications

Erik Rosenhahn, Thomas James O’Brien, Maha Saad Zaki, Ina Sorge, Dagmar Wieczorek, Kevin M. Rostasy, Antonio Vitobello, Sophie Nambot, Fowzan Sami Alkuraya, Mais O. Hashem, Amal Mohammed Alhashem, Brahim M. Tabarki, Abdullah Alamri, Ayat H. Al Safar, Dalal Bubshait, , Konrad Platzer

The American Journal of Human Genetics · Jul 12, 2022Peer-reviewedGenetic & Genomic Medicine