NeuroscienceJournal of NeurosciencePeer-reviewed
Calcium-dependent regulation of neuronal excitability is rescued in Fragile X Syndrome by a tat-conjugated N-terminal fragment of FMRP
Xiaoqin Zhan, Hadhimulya Asmara, Paul J. Pfaffinger, Ray W. Turner
This study identifies a Cav3-Kv4 complex regulated by FMRP that controls neuronal excitability, and shows that FMRP-N-tat peptide treatment rescues this function in Fragile X Syndrome models.
7 citations