Author

Rosalie Lipsh-Sokolik

Eidgenössische Technische Hochschule (ETH) ZurichORCID 0000-0002-5548-7309Unclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 1

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

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Jörn PieliD· 1 shared Thomas Henri JordaniD· 1 shared

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2026-2026 · peak 1/yr

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Jörn PielORCID

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Synthetic BiologybioRxivPreprintNov 3, 2026

Mapping and Probing the Substrate Scope of a Ketoamide-Forming Splicease by Computational Design

Thomas Henri Jordan, Rosalie Lipsh-Sokolik, Jörn Piel

The paper uses computational methods to design and evaluate splicease variants for generating diverse ketoamide substrates, finding that top-scoring peptides are spliced more efficiently than single-point mutants.

DOI 10.64898/2026.11.03.763875

protein structureprotein sequence

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