Jörn Piel

Mapping and Probing the Substrate Scope of a Ketoamide-Forming Splicease by Computational Design

The paper uses computational methods to design and evaluate splicease variants for generating diverse ketoamide substrates, finding that top-scoring peptides are spliced more efficiently than single-point mutants.

Dynamic evolution of diaphorin biosynthetic genes against a background of genome conservation in Profftella

The paper compares Profftella genomes across Diaphorina species, finding conserved gene organization but lineage-specific variation in diaphorin biosynthetic genes, particularly in ACP domain amplification.

Genome-resolved diversity and biosynthetic potential of the coral reef microbiome

This study assesses the microbial biosynthetic potential of reef-building corals using genome-resolved metagenomics, revealing host-specific microbiomes with high biotechnological value.

The Gfr uptake system provides a context-dependent fitness advantage to Salmonella Typhimurium SL1344 during the initial gut colonization phase

The paper shows that the gfr operon in Salmonella Typhimurium provides a fitness advantage during gut colonization by utilizing dietary Amadori compounds like fructoselysine.