Cytolethal distending toxin promotes epithelial-to-mesenchymal transition by modulating AKT-Dependent β-catenin Ser552 phosphorylation
Ruxue Jia, Lamia Azzi Martin, Mariana Saraiva, Elodie Sifré, Christine Varon, Pierre R. Dubus, Armelle Ménard
This study shows that CDT induces β-catenin Ser552 phosphorylation via AKT, leading to EMT and cancer-related changes in epithelial cells.
bioRxiv · Jun 3, 2026 · PreprintCancer Biology