Synthetic BiologyProceedings of the National Academy of SciencesPeer-reviewed
Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation
Tae-Eun Kim, Kotaro Tsuboyama, Scott Houliston…·Gabriel J. Rocklin
The paper designs over ten thousand {square}{beta}{beta}{square} proteins, identifies stability determinants, and demonstrates how high-throughput methods can improve protein design success rates.
25 citations