Claire M. Phoumyvong

The paper compares the molecular and functional effects of a PACS1 variant (p.R203W) with complete PACS1 loss-of-function in iPSC-derived neurons, finding distinct phenotypes suggesting a non-loss-of-function mechanism.

The paper measures protein stability for 1.8 million domains using a new experimental method and develops models that accurately predict stability with high precision.

The paper measures conformational fluctuations of protein domains using hydrogen-deuterium exchange mass spectrometry and uses computational modeling to design mutations that stabilize low-stability segments.

The paper designs over ten thousand {square}{beta}{beta}{square} proteins, identifies stability determinants, and demonstrates how high-throughput methods can improve protein design success rates.

The paper constructs a coessential genetic network to map the dynamic cellular stress response across 625 cancer cell lines, identifying key regulators and modules involved in stress resilience.