Cydney M. Martell

Large-scale discovery, analysis, and design of protein energy landscapes

The paper measures conformational fluctuations of protein domains using hydrogen-deuterium exchange mass spectrometry and uses computational modeling to design mutations that stabilize low-stability segments.

Global Analysis of Aggregation Determinants in Small Protein Domains

The paper quantifies aggregation in small protein domains under stress and uses machine learning to identify predictors, improving aggregation prediction models.

Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation

The paper designs over ten thousand {square}{beta}{beta}{square} proteins, identifies stability determinants, and demonstrates how high-throughput methods can improve protein design success rates.