Jiandong Li

Within-host competition sparks pathogen molecular evolution and perpetual microbiota dysbiosis.

The paper shows that within-host competition between pathogens and microbiota drives molecular evolution and microbiota dysbiosis in C. elegans hosts.

Population Bottlenecks and Intra-host Evolution during Human-to-Human Transmission of SARS-CoV-2Population Bottlenecks and Intra-host Evolution during Human-to-Human Transmission of SARS-CoV-2

This study compares SARS-CoV-2 viral populations in COVID-19 patients to show narrow transmission bottlenecks and stochastic dynamics in intra-host and inter-host evolution.

Multiple approaches for massively parallel sequencing of HCoV-19 (SARS-CoV-2) genomes directly from clinical samples

This paper compares amplicon, hybrid capture, and metatranscriptomic sequencing methods for directly sequencing SARS-CoV-2 genomes from clinical samples, finding differences in bias, sensitivity, and accuracy.

Structural insight into the mechanism of neuraminidase inhibitor-resistant mutations in human-infecting H10N8 Influenza A virus

This paper identifies two drug-resistant mutations in H10N8 influenza virus and explains their structural mechanisms using crystallography, showing differences in resistance to neuraminidase inhibitors.

Recovered and dead outcome patients caused by influenza A (H7N9) virus infection show different pro-inflammatory cytokine dynamics during disease progress and its application in real-time prognosis

This study analyzes cytokine dynamics in H7N9-infected patients with different outcomes, identifying predictors and a real-time prognosis model.