Monica Sundd

This paper identifies a thioester-thiol exchange reaction in IacP that transfers the 4PP-bound acyl chain to a distal cysteine, revealing a mechanism for SipB acylation in Salmonella.

The paper identifies a single mutation (D35N) in the DSL motif of acyl carrier proteins (ACP) that prevents in vivo modification by E. coli AcpS, enabling the expression of apo-ACP and demonstrating its applicability across different ACPs.