Yasushi Sakata

This study identifies CR9 as a stress-inducible hub enhancer critical for natriuretic peptide expression in heart failure, showing its reversible activation in human hearts.

This study identifies a variant in the ACTB gene associated with orofacial clefts in BWCFF and shows it impairs actin dynamics and epithelial cell function.

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

This study identifies three new CAD loci through transethnic GWAS and highlights population-specific genetic differences between Japanese and European populations.

This study identifies novel genetic loci for coronary artery disease in Japanese and transethnic populations and develops a polygenic risk score that outperforms population-specific scores.