Hiroshi Kurosaka

This study identifies TMEM2 as a regulator of hyaluronan turnover in articular cartilage, showing its role in maintaining ECM integrity during osteoarthritis progression.

This study shows retinoid signaling specifies frontonasal identity and represses maxillary identity in cranial neural crest cells during facial development in mice.

The paper identifies a Wnt-responsive fibrocartilage progenitor system that coordinates postnatal mandibular condylar cartilage growth through Foxm1-dependent proliferation and suppression of TGF-β-driven chondrogenic differentiation.

This study identifies a variant in the ACTB gene associated with orofacial clefts in BWCFF and shows it impairs actin dynamics and epithelial cell function.

This study shows that SLC26A2-mediated sulfate metabolism is essential for tooth development, as its deficiency leads to craniofacial abnormalities and tooth hypoplasia in mice.

This paper shows that TMEM2, a cell surface hyaluronidase, is essential for neural crest cell development and survival in mice, as its absence causes craniofacial and cardiovascular defects.

The paper infers gene regulatory networks from time-course bulk RNA-Seq data to reveal both intracellular and intercellular regulatory relationships during development.

The paper shows that Cbfb is essential for anterior palatogenesis and that folic acid rescues cleft palate by restoring Stat3 phosphorylation and Tgfb3 expression in vitro.