Claudia Maria Assunta Pinna

This paper develops a low-matrix co-culture platform to evaluate T cell engager activity in patient-derived CRC organoids, showing dose-dependent cytotoxicity and immune activation across diverse models.

The paper shows that germline mutations in POLE or POLD1 lead to elevated mutation burdens in normal human cells and tissues, but do not cause premature aging or other phenotypic features beyond early-onset cancer.