A low-matrix organoid-T cell co-culture platform for functional evaluation of T cell engagers in patient-derived colorectal cancer organoids
Claudia Maria Assunta Pinna, Kamila Rakhimova, Jing Zhang, Laura Bills, Louise Tee, Charlotte Blanc, David G. Millar, Elsa Rottoli, Oisín Huhn, Miguel Gaspar, Neeraj Lal, Romain Lara, Kaitlin A. Marley, Sašo Čemerski, Simon J. Dovedi, Andrew David Beggs
This paper develops a low-matrix co-culture platform to evaluate T cell engager activity in patient-derived CRC organoids, showing dose-dependent cytotoxicity and immune activation across diverse models.
bioRxiv · Sep 27, 2026 · PreprintCancer Biology