NeurosciencebioRxivPreprint
Ketamine strengthens synaptic inputs to the dorsal raphe to boost serotonergic activity: pivotal for rapid antidepressant-like effects
Soukaina Es-Safi, Céline Bourcier‐Lucas, Erika Abrial…·Guillaume Lucas
This study shows low-dose ketamine increases synaptic inputs to serotonergic neurons in the dorsal raphe, boosting serotonin release and hippocampal neurogenesis, linking rapid antidepressant effects to serotonergic plasticity.
DOI 10.1101/2025.10.24.684353