Adeline Cathala

Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD

This study identifies PAI-1 as a blood biomarker and brain risk factor for PTSD, showing increased levels in PTSD-like models and soldiers with PTSD symptoms.

Ketamine strengthens synaptic inputs to the dorsal raphe to boost serotonergic activity: pivotal for rapid antidepressant-like effects

This study shows low-dose ketamine increases synaptic inputs to serotonergic neurons in the dorsal raphe, boosting serotonin release and hippocampal neurogenesis, linking rapid antidepressant effects to serotonergic plasticity.

Pregnenolone and AEF0117 block cannabinoid-induced hyperlocomotion through GSK3β signaling at striatopallidal neurons

This study shows that pregnenolone and AEF0117 block THC-induced hyperlocomotion by inhibiting CB1R-mediated GSK3β signaling in striatopallidal neurons.

Midbrain dopamine D2R regulates the salience of threat-related events

This study investigates the role of dopamine D2 autoreceptors in regulating VTA dopamine neuron responses to aversive stimuli and finds they act as a regulatory brake with sex-biased effects on threat processing.