Ketamine strengthens synaptic inputs to the dorsal raphe to boost serotonergic activity: pivotal for rapid antidepressant-like effects
Soukaina Es-Safi, Céline Bourcier‐Lucas, Erika Abrial, Adeline Cathala, Thierry Lesté-Lasserre, Philippe De Deurwaerdère, Jean‐Michel Revest, Jean Mazella, Nasser Haddjeri, Guillaume Lucas
This study shows low-dose ketamine increases synaptic inputs to serotonergic neurons in the dorsal raphe, boosting serotonin release and hippocampal neurogenesis, linking rapid antidepressant effects to serotonergic plasticity.
bioRxiv · Oct 24, 2025 · PreprintNeuroscience