Molecular kinetics dictate population dynamics in CRISPR-based plasmid defense
Luke Richards, Danna Lee, Jakub Wiktor, Axel Truedson, Johanna Cederblad, Daniel Jones
The paper uses time-lapse imaging to study CRISPR-Cas dynamics in bacterial plasmid defense, finding that Cascade provides partial plasmid clearance with tradeoffs between clearance and cell growth.
Proceedings of the National Academy of Sciences · Mar 30, 2026Peer-reviewedMolecular Biology