Daniel C. Jones

This study identifies molecular and architectural changes in normal-adjacent field tissue in HNSCC that disrupt epithelial differentiation and may promote cancer development.

The paper uses time-lapse imaging to study CRISPR-Cas dynamics in bacterial plasmid defense, finding that Cascade provides partial plasmid clearance with tradeoffs between clearance and cell growth.

This paper introduces a cell segmentation method using cell simulation to improve accuracy in single-cell spatial transcriptomics, showing better performance than existing methods in identifying tumor infiltrating immune cells.

This study identifies Sema4A as an extrinsic factor that protects myeloid-biased HSCs from inflammatory stress, preserving functional diversity in the hematopoietic stem cell pool.

This paper introduces Maxspin, an information-theoretic method for detecting spatially varying genes, showing improved accuracy across spatial transcriptomics platforms and simulations.

Polee approximates the likelihood function of a sparse mixture model for RNA-Seq analysis, improving differential transcript expression detection with reduced computational costs.

Isolator improves isoform-level RNA-Seq analysis by reducing variance and increasing agreement between samples through a Bayesian hierarchical model and bias correction.