Wenfeng An

The paper demonstrates somatic L1 retrotransposition in adult mouse liver using an intrahepatic reporter assay and identifies distinct regulatory mechanisms in tumor versus normal cells.

This study shows YY1 activates mouse LINE-1 Tf subfamily transcription by binding to its 5UTR and enabling synergistic monomer interactions.

The paper compares promoter activities across young mouse L1 subfamilies and identifies the differential contribution of individual monomers and the tether sequence to promoter activity.

The paper identifies heterogeneity in L1-ORF1p expression and its relationship with piRNA pathway activation and H3K9me3 levels in human fetal germ cells.