Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility
Sumasri Guntupalli, Pojeong Park, Dae Hee Han, Lingrui Zhang, Xuan Ling Hilary Yong, Mitchell Ty Ringuet, Daniel G. Blackmore, Dhanisha J. Jhaveri, Frank Köentgen, Jocelyn Widagdo, Bong‐Kiun Kaang, Victor Anggono
This study shows that GluA1 ubiquitination at K868 is essential for LTD, spatial memory, and cognitive flexibility, but not for basal synaptic transmission or LTP.
Journal of Neuroscience · Jul 7, 2023Peer-reviewedNeuroscience