Jocelyn Widagdo

This study identifies Copine-6 as a protein that links calcium, phosphoinositide, and Rab11 signals to regulate glutamate receptor recycling in neurons.

This paper identifies Copine-6 as a Ca2+ sensor that mediates activity-induced AMPA receptor exocytosis, distinct from Syt-1 and Syt-7.

This study identifies distinct roles of low-complexity regions in SFPQ for biomolecular condensate formation, showing the C-terminal region drives condensation while the N-terminal region inhibits it.

This study shows that GluA1 ubiquitination at K868 is essential for LTD, spatial memory, and cognitive flexibility, but not for basal synaptic transmission or LTP.

This study shows that ALS-linked SFPQ mutations increase zinc binding and cytoplasmic aggregation, reducing surface AMPA receptor subunit GluA1 in neurons.

This study identifies CaMKIIα-mediated phosphorylation of GluN2A at Ser-1459 as a mechanism regulating NMDAR trafficking and gating, with implications for epilepsy.