Victor Anggono

Copine-6 integrates calcium, phosphoinositide and Rab11 signals to coordinate glutamate receptor recycling

This study identifies Copine-6 as a protein that links calcium, phosphoinositide, and Rab11 signals to regulate glutamate receptor recycling in neurons.

Axonal swelling as a neuron-specific compartment to sequester and expel misfolded proteins

The paper identifies a neuron-specific quality-control compartment, SolAS, that sequesters and expels misfolded proteins, showing its role in proteostasis during aging.

DDHD2 provides a critical flux of saturated fatty acids to support neuronal energy demands

The paper shows that DDHD2-generated saturated fatty acids are essential for neuronal energy production and synaptic function.

Local translation of circular RNAs is required for synaptic activity and memory

The paper identifies local translation of circular RNAs in the prefrontal cortex of mice, revealing a micropeptide involved in synaptic activity and memory.

Tau controls NMDA receptor trafficking during homeostatic synaptic plasticity

This study identifies Tau as a regulator of NMDA receptor trafficking during homeostatic synaptic plasticity, showing that Tau phosphorylation and interactions with Fyn kinase modulate receptor stability.

Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis

This paper identifies Copine-6 as a Ca2+ sensor that mediates activity-induced AMPA receptor exocytosis, distinct from Syt-1 and Syt-7.

Different low-complexity regions of SFPQ play distinct roles in the formation of biomolecular condensates

This study identifies distinct roles of low-complexity regions in SFPQ for biomolecular condensate formation, showing the C-terminal region drives condensation while the N-terminal region inhibits it.

Ubiquitination of the GluA1 subunit of AMPA receptors is required for synaptic plasticity, memory and cognitive flexibility

This study shows that GluA1 ubiquitination at K868 is essential for LTD, spatial memory, and cognitive flexibility, but not for basal synaptic transmission or LTP.

Synapse-specific trapping of Syntaxin1a into nanoclusters by the general anesthetic isoflurane

This study shows isoflurane selectively impairs Syntaxin1A activity at cholinergic synapses in Drosophila excitatory neurons, but not in inhibitory neurons.

Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates that reduce surface AMPA receptor expression in primary neurons

This study shows that ALS-linked SFPQ mutations increase zinc binding and cytoplasmic aggregation, reducing surface AMPA receptor subunit GluA1 in neurons.

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

This study identifies CaMKIIα-mediated phosphorylation of GluN2A at Ser-1459 as a mechanism regulating NMDAR trafficking and gating, with implications for epilepsy.

Native KCC2 Interactome Reveals PACSIN1 As A Critical Regulator Of Synaptic Inhibition

The paper identifies PACSIN1 as a key negative regulator of KCC2 function through a native KCC2 interactome analysis in the mouse brain.