Pojeong Park

The paper shows that synaptic depression between memory-encoding engram cells impairs memory, demonstrating that synaptic plasticity between these cells causally supports memory.

This study measures the voltage-to-Ca2+ transfer function in hippocampal CA2 pyramidal neurons during behavior and develops a biophysics-inspired model to predict Ca2+ signals from voltage waveforms.

This study maps dendritic membrane potential dynamics in CA1 neurons during behavior, showing dendritic spikes are driven by back-propagating action potentials and influence spiking outputs and plasticity.

DENDRO recovers and denoises 3D dendritic voltage from 2D voltage movies using a microscope model and a self-supervised neural network, achieving high accuracy on simulated and real data.

The paper investigates dendritic excitations in CA1 pyramidal neurons, showing how locally generated Na+ spikes drive history-dependent spike back-propagation and influence associative plasticity.

The paper investigates the photophysics of FRET-opsin voltage indicators and demonstrates two-photon voltage imaging in live mice using optimized protocols.

The paper introduces Solaris, a hybrid voltage indicator with improved sensitivity for imaging membrane potential in cultured neurons.

This study shows that GluA1 ubiquitination at K868 is essential for LTD, spatial memory, and cognitive flexibility, but not for basal synaptic transmission or LTP.

The paper introduces EPSILON, a technique to map AMPA receptor dynamics during memory formation and finds a correlation between synaptic plasticity and cFos expression.

The paper measures voltage dynamics in dendrites of mice neurons during synaptic input integration and action potential propagation, finding shared membrane voltage and rate-dependent propagation of back-propagating action potentials.

The paper develops a protein-based ticker tape system to record neural activation histories with high temporal resolution.

SUPPORT is a self-supervised method that denoises voltage imaging data by leveraging spatiotemporal dependencies, preserving dynamics without requiring action potential information.

The paper shows that specific dendritic branches in cortical layer 2/3 pyramidal cells fail to evoke calcium influx from bAPs due to branch-specific properties, despite having functional VGCCs.

The paper introduces improved genetically encoded voltage indicators for all-optical electrophysiology, revealing interneuron network dynamics in live mice.

The paper shows that associative fear memory increases spine size at synapses between engram cells in the amygdala, which decreases with extinction and recovers with re-conditioning.

The paper provides pharmacological evidence supporting the role of CP-AMPARs in synaptic tag and capture at hippocampal CA1 synapses through experimental validation of predicted effects.

The paper shows that LTP in hippocampal synapses can increase AMPA receptor number or conductance, with distinct mechanisms involving CaMKII and PKA.