Tom P. Freeman

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

This study investigates how THC and CBD affect CB1 and CB2 receptor-enriched functional connectivity using REACT analysis in cannabis users.

This study examines the effects of regular cannabis use on brain resting-state functional connectivity in adolescents and adults, finding localized increases in the executive control network in users but no significant age-group interactions.

This paper uses neuroimaging meta-regression to examine THC's acute effects on brain activation and its relationship with CB1R gene expression.

This study investigates the acute effects of CBD on emotional processing and anxiety using neuroimaging and cognitive measures, finding no significant effects compared to placebo.

This study examines how CBD and THC affect striato-cortical connectivity in the human brain using fMRI, finding THC disrupts connectivity while CBD mitigates some effects and has mixed impacts when used alone.

This study examines whether cannabis use extent predicts psychotic-like and euphoric intoxication experiences in First Episode Psychosis patients and controls, finding a significant interaction between caseness and use frequency.

The paper examines the independent and combined effects of schizophrenia polygenic risk score and heavy cannabis use on psychotic disorder risk using EUGEI data, finding both factors independently increase risk.

This study examines the relationship between cannabis use and symptom profiles in first episode psychosis patients and population controls, finding that cannabis use correlates with positive symptoms and negative symptoms in patients.