Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity
Syed Ali Raza, Yoshimi Enose‐Akahata, Anna S. Blazier, Lauren Guerra, Erin Beck, María Inés Gaitán, Nyater Ngouth, Jefte M. Drijvers, Eric B. Dammer, Devan Moodley, Kory R. Johnson, Martina Absinta, Valeria Ramaglia, Jennifer L. Gommerman, Timothy Turner, , Daniel S. Reich
This study identifies chronic neuroinflammation in MS through scRNA-seq and proteomics, showing persistent IFN signaling and CD8 T cell cytotoxicity despite B-cell depletion.
bioRxiv · Jun 9, 2025 · PreprintImmunology