Jennifer L. Gommerman

This study shows that NOD2 signaling in endothelial cells regulates intestinal immune responses by promoting T cell homing and memory formation, and its loss contributes to Crohn's disease inflammation.

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

The paper examines B cell dynamics in different meningeal compartments of a progressive MS mouse model, identifying anti-CD20 resistant dural B cells that persist in the brain during remission.

This study identifies chronic neuroinflammation in MS through scRNA-seq and proteomics, showing persistent IFN signaling and CD8 T cell cytotoxicity despite B-cell depletion.

This study identifies unconventionally primed TFH1 cells as essential for generating IgA+ long-lived plasma cells during mucosal viral infections.

This study shows that antibodies and neutrophils, not complement, are critical for protecting against nasal colonization by Neisseria meningitidis.

This study identifies specific iNKT cell subsets in mice and humans with enhanced antitumor activity, suggesting potential improvements for adoptive cell therapies.

The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.

The paper investigates complement system involvement in synapse loss in MS hippocampus, finding C1q deposits linked to inhibitory synapse loss and impaired memory.