Kory R. Johnson

This study identifies TNIP1 and autophagy receptors as regulators of STING signaling, showing their roles in immune responses and vesicle clustering.

The paper identifies variable merlin inactivation in schwannomas and shows TEAD1 inhibition can reverse hippo signaling and suppress tumor growth.

The paper identifies BORC as a modifier of TDP-43 protein levels in neurons, showing lysosome transport is required for TDP-43 turnover.

This study characterizes a new pluripotent state in RSeT hESCs, showing resistance to naive and formative conversion and distinct transcriptomic and signaling features.

This study identifies chronic neuroinflammation in MS through scRNA-seq and proteomics, showing persistent IFN signaling and CD8 T cell cytotoxicity despite B-cell depletion.

This paper develops 3D brain organoids with endothelial and neural cells using sequential differentiation of iPSC-derived embryoid bodies, showing enhanced angiogenesis and SARS-CoV-2 receptor expression.

This study shows targeting ZNF638 induces viral mimicry and enhances immune checkpoint inhibition in glioblastoma by increasing dsRNA signaling and PD-L1 expression.

This study identifies divergent gene expression in AUD and OUD but finds shared biological pathways in the dorsolateral prefrontal cortex, suggesting potential therapeutic targets.

The paper identifies DELE1's role in promoting translation-associated homeostasis, growth, and survival in mitochondrial myopathy through the mt-ISR pathway.

This study uses allele-specific CRISPR/Cas9 to inactivate a pathogenic variant in COL6A1, showing improved editing efficiency and collagen VI matrix restoration in patient fibroblasts.

The paper shows zebrafish stripe patterns arise from in situ differentiation of iridophore crystallotypes, not migration, with distinct transcriptomic and physiological states in stripe and interstripe regions.