Dimitry Ofengeim

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

This study identifies chronic neuroinflammation in MS through scRNA-seq and proteomics, showing persistent IFN signaling and CD8 T cell cytotoxicity despite B-cell depletion.

This study identifies genetic risk loci and candidate genes for inflammatory polyneuropathy and CIDP through GWAS and functional analyses.

This paper compares the CNS pharmacology of three BTK inhibitors in non-human primates, finding that tolebrutinib achieves higher CSF exposure than the others.

This study identifies glial state changes and RIPK1 signaling as key features of ALS pathogenesis, showing that blocking RIPK1 delays disease onset and modulates glial responses.

The paper shows microglia are susceptible to ferroptosis in neurodegenerative diseases and identifies SEC24B and small molecules that regulate this process.

This study identifies SPMS-enriched microglia subsets with disrupted iron homeostasis and oxidative stress using snRNA-seq and validates findings with histology and RNA-scope.

The paper shows that calcium accumulations in dendritic spines precede their removal by phagocytes in cortical inflammation, and blocking phagocyte activation prevents synapse loss.