Reanalysis of public environmental metatranscriptomes from the Huanan market links SARS-CoV-2 positivity to one wildlife stall containing raccoon dog, civet and bamboo rat genetic material.

Cell · Sep 1, 2024Peer-reviewedGenomics✦ In-depth digest

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

Kayla G. Barnes, Anna E. Lachenauer, Adam D. Nitido, Sameed M. Siddiqui, Robin Gross, Brett F. Beitzel, Katherine J. Siddle, Catherine A. Freije, Bonnie Dighero-Kemp, Samar B. Mehta, Amber Carter, Jessica N. Uwanibe, Fehintola Victoria Ajogbasile, Testimony Jesupamilerin Olumade, Ikponmwosa Odia, , Pardis Christine Sabeti

This paper develops CRISPR-Cas13a-based diagnostics for real-time detection of Ebola and Lassa viruses in field settings, demonstrating sensitivity and usability in clinical samples.

Nature Communications · Aug 17, 2020Peer-reviewedMolecular Biology

Machine-Learning prognostic models from the 2014-16 Ebola outbreak: data-harmonization challenges, validation strategies, and mHealth applications

Andrés Colubri, Mary‐Anne Hartley, Matthew Siakor, Vanessa Wolfman, August Felix, Tom Sesay, Jeffrey G. Shaffer, Robert F. Garry, Donald Samuel Grant, Adam C. Levine, Pardis Christine Sabeti

The paper develops machine-learning prognostic models for Ebola virus disease using data from the 2014-16 outbreak, validated across independent datasets and integrated into a mobile health app.

EClinicalMedicine · May 1, 2019Peer-reviewedBioinformatics