Author

Kayla G. Barnes

Broad InstituteORCID 0000-0002-8291-4388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aaron E. LiniD· 4 shared Pardis Christine SabetiiD· 4 shared Daniel J. ParkiD· 3 shared Hayden C. MetskyiD· 3 shared Katherine J. SiddleiD· 3 shared Lisa E. HensleyiD· 3 shared Shirlee WohliD· 3 shared Adrianne D. GladdeniD· 2 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenomics

Aaron E. LinORCID

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4 papers

Recent·Most cited

In vivo single-cell profiling of lncRNAs during Ebola virus infection

Luisa Santus, Raquel García-Pérez, Maria Sopena-Rios, Aaron E. Lin, Gordon C. Adams, Kayla G. Barnes, Katherine J. Siddle, Shirlee Wohl, Ferrán Reverter, John L. Rinn, Richard S Bennett, Lisa E. Hensley, Pardis Christine Sabeti, Marta Melé

This study profiles lncRNA expression in single cells during Ebola virus infection in vivo, revealing cell-type specific changes and potential roles in immune response and viral hijacking.

bioRxiv · Jan 12, 2022 · PreprintGenomics

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

Kayla G. Barnes, Anna E. Lachenauer, Adam D. Nitido, Sameed M. Siddiqui, Robin Gross, Brett F. Beitzel, Katherine J. Siddle, Catherine A. Freije, Bonnie Dighero-Kemp, Samar B. Mehta, Amber Carter, Jessica N. Uwanibe, Fehintola Victoria Ajogbasile, Testimony Jesupamilerin Olumade, Ikponmwosa Odia, , Pardis Christine Sabeti

This paper develops CRISPR-Cas13a-based diagnostics for real-time detection of Ebola and Lassa viruses in field settings, demonstrating sensitivity and usability in clinical samples.

Nature Communications · Aug 17, 2020Peer-reviewedMolecular Biology

Capturing diverse microbial sequence with comprehensive and scalable probe design

Hayden C. Metsky, Katherine J. Siddle, Adrianne D. Gladden, James Qu, David K. Yang, Patrick Brehio, Andrew Goldfarb, Anne L Piantadosi, Shirlee Wohl, Amber Carter, Aaron E. Lin, Kayla G. Barnes, Damien C. Tully, Björn Corleis, Scott Hennigan, , Christian B. Matranga

The paper introduces CATCH, a method for designing compact and scalable probe sets to enhance metagenomic sequencing sensitivity, demonstrating improved viral genome recovery and diversity preservation.

Nature Biotechnology · Feb 1, 2019Peer-reviewedGenomics

Genome sequencing reveals Zika virus diversity and spread in the Americas

Hayden C. Metsky, Christian B. Matranga, Shirlee Wohl, Stephen F. Schaffner, Catherine A. Freije, Sarah M. Winnicki, Kendra L. West, James Qu, Mary Lynn Baniecki, Adrianne D. Gladden, Aaron E. Lin, Christopher H. Tomkins-Tinch, Simon H. Ye, Daniel J. Park, Cynthia Y. Luo, , Pardis Christine Sabeti

This study sequenced 110 Zika virus genomes from 10 countries, revealing rapid expansion in Brazil, multiple introductions into other regions, and undetected circulation before confirmed cases.

Nature · May 23, 2017Peer-reviewedGenomics