Ritesh Kumar Aggarwal

In vivo anti-tumor activity of high-dose parenteral ascorbic acid is mediated primarily via cofactor activity, not via oxidative stress.

This study shows that high-dose parenteral ascorbic acid's anti-tumor effect in vivo is mainly due to cofactor activity, not oxidative stress, using mouse tumor models.

Deconstructing glucose-mediated catabolite repression of the lac operon of Escherichia coli: II. Positive feedback exists and drives the repression

The paper investigates whether lactose enzymes promote allolactose accumulation during lac operon induction and repression in E. coli, finding that positive feedback exists and reverses under different conditions.

Deconstructing glucose-mediated catabolite repression of the lac operon of Escherichia coli: I. Inducer exclusion, by itself, cannot account for the repression.

The paper investigates glucose-mediated repression of the lac operon in E. coli, showing that inducer exclusion alone cannot account for the repression and that positive feedback plays a major role when chloramphenicol is absent.