Lie Wang

The paper constructs a single-cell GEX-TCR reference atlas and introduces TCR-DeepInsight, a deep-learning framework to characterize disease-associated TCRs.

The paper introduces MCGLPPI, a geometric representation learning framework that combines graph neural networks with a molecular coarse-grained model to predict PPI properties efficiently.

This study shows that CXXC1 interacts with FOXP3 to regulate Treg cell function and epigenetic stability, essential for immune homeostasis and preventing inflammation.