Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradation
Erik Ehinger, Kristy C. Perez, Emi Sanchez, Bruno Villalobos Reveles, Barsha Dash, Leo J. Arteaga-Vazquez, Eric Johnson, Anjana Rao, Patrick G. Hogan
The paper shows that targeted degradation of NR4A proteins in T cells reverses exhaustion by restoring effector function and reducing inhibitory receptors.
bioRxiv · Feb 4, 2026 · PreprintImmunology