Patrick G. Hogan

The atypical IκB factor IκBδ enhances CD8 T cell accumulation and effector functions in solid tumors

This study identifies IκBδ as a factor that enhances CD8 T cell accumulation and effector functions in solid tumors by overcoming constraints on T cell survival and cytotoxic capacity.

Reversible control of T cell exhaustion by NR4A transcription factors revealed through targeted protein degradation

The paper shows that targeted degradation of NR4A proteins in T cells reverses exhaustion by restoring effector function and reducing inhibitory receptors.

Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causingautoimmune diseases through autoantibody production

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

Proteome-wide base editor screens to assess phosphorylation site functionality in high-throughput

The paper uses base editor screens to assess phosphorylation site functionality in T cell activation, identifying novel sites that modulate transcriptional activity and signaling pathways.