Leo J. Arteaga-Vazquez

This study identifies IκBδ as a factor that enhances CD8 T cell accumulation and effector functions in solid tumors by overcoming constraints on T cell survival and cytotoxic capacity.

The paper shows that targeted degradation of NR4A proteins in T cells reverses exhaustion by restoring effector function and reducing inhibitory receptors.

This study shows TET2 regulates 5hmC deposition in adult neural stem cells, balancing stemness and differentiation through distinct epigenetic programs.

This study shows that loss of TET function in Treg cells leads to ex-Treg cells that differentiate into Tfh cells, promoting autoantibody production and autoimmune disease.

This study links increased transposable element (TE) expression in SLE patients to IFN responses, showing strong correlations with disease activity and splicing alterations.

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

This study shows that mutant ASXL1 proteins disrupt heterochromatin integrity in clonal hematopoiesis and CMML by reducing H3K9me2/3 and H2AK119Ub, leading to increased transposable element expression.