Biomarker-Targeted O6-Guanine Alkylation Potentiates ATR Inhibitor Response in De Novo and Relapsed/Refractory AML
Prateek Bhardwaj, Amro Baassiri, Ranjini K. Sundaram…·Ranjit S. Bindra
This study identifies MGMT silencing as a therapeutic target in AML and shows that combining O6-fluoroethylating agents with ATR inhibitors improves treatment outcomes.