Hao Ge

scSTEC directly annotates chromatin subcompartments from individual single-cell Hi-C matrices without imputation or cross-cell sharing, achieving results comparable to scGHOST with greater interpretability.

scDIAGRAM detects chromatin compartments in single-cell Hi-C data without imputation or reference features, showing accuracy in simulated and real datasets.

This paper presents a non-invasive preimplantation genetic testing method using spent embryo culture medium, achieving high accuracy for monogenic and polygenic disease detection without modifying IVF workflows.

The paper reveals that pioneer transcription factors use mesoscale chromatin confinement to efficiently search for and bind to closed chromatin regions in live cells.

This paper introduces COSLIR, a method to directly reconstruct gene regulatory networks from time-stamped single-cell data without pseudo-time inference, showing good performance on real datasets.

The paper develops a mathematical model to uncover the nonequilibrium mechanism behind drug synergy between Activators and Noise Enhancers in HIV latency reactivation.

SCRIBE imputes dropout events and corrects batch effects in scRNA-seq data, improving recovery of cell-specific gene expression and biological variation.