Zaoke He

This study identifies a RIPK2-regulated gene signature that correlates with prognosis in prostate cancer and responds to RIPK2 inhibitors.

The paper identifies FLAD1 as a key gene for hypoxia adaptation in tumors and develops a deep learning model to predict hypoxia-dependent metabolic genes.

This study shows that Ggct deletion in mice causes splenomegaly and anemia due to oxidative damage and reduced glutathione in red blood cells.

This study identifies five copy number signatures in prostate cancer using sigminer, revealing distinct etiologies and improved clinical outcome associations compared to single base substitution signatures.

This paper critiques a previous study that claimed no neoantigen depletion signal in untreated cancer genomes, arguing that the study's methodology is flawed due to misalignment between defined HLA-binding regions and actual immunogenic neoantigens.