Angelika Schnieke

The paper shows bacterial invasion and neutrophil immunosuppression drive adenoma progression in a porcine FAP model using single-cell RNA sequencing and spatial transcriptomics.

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

The paper identifies a recessive allele in WDR19 associated with reduced semen quality and male fertility in cattle, showing it activates cryptic splicing and reduces protein expression.

This paper generates Cas9-expressing transgenic chickens and pigs for in vivo genome editing, demonstrating their health, fertility, and functionality across multiple tissues and genes.

The paper identifies a frameshift mutation in GON4L causing dwarfism in Fleckvieh cattle by linking it to growth restriction and craniofacial abnormalities through genomic analysis.