Krzysztof Flisikowski

The paper shows bacterial invasion and neutrophil immunosuppression drive adenoma progression in a porcine FAP model using single-cell RNA sequencing and spatial transcriptomics.

This study evaluates virus-like particles (VLPs) as efficient delivery vehicles for genome editing tools in pigs and chickens, achieving high editing rates in various cell types and systems.

The paper demonstrates that formaldehyde vapor fixation preserves porcine lung tissue for high-resolution phase contrast CT imaging and histology, validating its use for studying lung pathology.

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

The paper performs genome-wide methylation profiling to identify differentially methylated regions in adipose stem cells with high and low cloning efficiency in pigs.

The paper identifies a recessive allele in WDR19 associated with reduced semen quality and male fertility in cattle, showing it activates cryptic splicing and reduces protein expression.

This paper generates Cas9-expressing transgenic chickens and pigs for in vivo genome editing, demonstrating their health, fertility, and functionality across multiple tissues and genes.

The paper identifies a splice donor variant in CCDC189 associated with asthenospermia in Nordic Red cattle and integrates findings into the OMIA database.

The paper identifies a frameshift mutation in GON4L causing dwarfism in Fleckvieh cattle by linking it to growth restriction and craniofacial abnormalities through genomic analysis.