Haowei Jiang

The paper compares the effects of frameshift and frame-preserving mutations in zebrafish psen2 on gene expression in young adult brains, identifying distinct cellular pathways affected.

The paper analyzes the transcriptome of zebrafish with a psen2 mutation to identify dominant effects on ribosome, mitochondrial, and anion transport functions.

This paper investigates the role of zebrafish psen2 mutations in melanotic skin pigmentation, finding that specific mutations affect pigmentation without causing lethality.

The paper develops ratiometric assays in zebrafish to measure autophagic flux in models of familial Alzheimer’s disease mutations, finding altered flux in several genetic models.