Yang Dong

The paper introduces Palette, a method to infer spatial gene expression from bulk RNA-seq data, and constructs DreSTEP, a resource for studying gene expression and spatial interactions in zebrafish embryos.

This study shows Mycn regulates vascular development in zebrafish by promoting cell proliferation and that PI3K signaling can rescue vascular defects caused by Mycn deficiency.

This study identifies Angptl5 as a regulator of hematopoietic homeostasis in zebrafish by modulating retinoic acid signaling, leading to myeloid hyperplasia and erythroid expansion in mutants.

This study shows that BMP4 alone can induce a caudal organizer in zebrafish embryos and human pluripotent stem cells, replicating developmental processes seen in natural development.

The paper shows that Ripply1 and Gsc suppress anterior endoderm differentiation from prechordal plate progenitors by repressing sox32 through cis-element binding.

This study uses a zebrafish model of Feingold syndrome 1 to show that Mycn regulates intestinal development through ribosomal biogenesis and that leucine supplementation can rescue the intestinal defect.

The paper compares the effects of two PSEN1 mutations in zebrafish brains, finding distinct impacts on energy metabolism and signaling pathways linked to different diseases.

The paper analyzes the transcriptome of zebrafish with a psen2 mutation to identify dominant effects on ribosome, mitochondrial, and anion transport functions.

This study uses a zebrafish model of familial Alzheimer’s disease to show accelerated brain aging and transcriptional inversion linked to glucocorticoid resistance and immune pathway changes before histopathology.