Marta R. Hidalgo

Single cell landscape of sex differences in the different courses of multiple sclerosis

The paper analyzes single-cell data from multiple sclerosis patients to identify sex-specific molecular differences in brain and immune cells across disease progression.

Transposable elements as new players to decipher sex differences in Parkinson Disease

The paper analyzes transposable elements in Parkinson Disease datasets to build a cell-type specific atlas and explore their role in sex differences.

Uncovering sex differences in Parkinson's Disease through metaanalysis of single cell transcriptomic studies

This study identifies sex differences in gene expression, cell-cell communication, and pathway activation in Parkinson's Disease through meta-analysis of single-cell transcriptomic data.

Transcriptomic landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue

This study identifies sex-specific biomarkers and transcriptomic signatures in subcutaneous adipose tissue for obesity and T2D, highlighting sex differences in molecular mechanisms.

MetaFun: Unveiling sex differences in multiple omics studies through comprehensive functional meta-analysis

MetaFun performs functional meta-analysis of transcriptomic datasets to uncover sex differences across multiple omics studies.

The impact of sex on gene expression in the brain of schizophrenic patients: a systematic review and meta-analysis of transcriptomic studies

This paper identifies sex-based transcriptomic differences in schizophrenia patients across specific brain regions through meta-analysis of bulk RNA-sequencing studies.

An integrated approach to identify sex-specific genes, transcription factors, and pathways in Alzheimer's disease

This paper identifies sex-specific genes, transcription factors, and pathways in Alzheimer's disease using meta-analyses of transcriptomic data from the cerebral cortex and hippocampus.

The role of microRNAs to understand sex-based differences in Alzheimer's disease

This paper identifies sex-specific miRNA expression differences in Alzheimer's disease patients through meta-analysis of blood and brain samples, revealing distinct biological process associations in each sex.

A spinal cord injury time and severity consensus transcriptomic reference suite in rat reveals translationally-relevant biomarker genes

This study identifies severity- and phase-specific biomarker genes for spinal cord injury using transcriptomic analysis and develops a web tool for exploring results.

A Deep Transcriptome Meta-Analysis Reveals Sex-based Molecular Differences in Multiple Sclerosis

This study identifies sex-based molecular differences in multiple sclerosis through transcriptomic meta-analysis, revealing tissue-specific gene expression patterns and functional immune pathway alterations.

Unveiling Sex-based Differences in Parkinson's Disease: A Comprehensive Meta-analysis of Transcriptomic Studies

This study identifies sex-based differences in Parkinson's disease transcriptomics through meta-analysis of 267 samples across three brain regions, revealing sex-specific gene expression and pathway alterations.

Assessment of Sex Bias in Housekeeping Gene Expression in Adipose Tissue Through the Massive Analysis of Transcriptomics Data

This paper evaluates sex bias in housekeeping gene expression in adipose tissue using transcriptomics data and identifies sex-unbiased housekeeping genes suitable for use as internal controls.

Hepatic steatosis and steatohepatitis: a functional metaanalysis of sex-based differences in transcriptomic studies

This paper performs a meta-analysis of transcriptomic studies to identify sex-based differences in molecular mechanisms during the progression from NAFL to NASH.

Mechanistic modeling of the SARS-CoV-2 disease map

The paper presents a web interface for a mechanistic model of the SARS-CoV-2 disease map to infer gene expression-related activities and study intervention effects.

Functional signatures in non-small-cell lung cancer: a systematic review and meta-analysis of sex-based differences in transcriptomic studies

This study performs a meta-analysis of transcriptomic data to identify sex-based differences in functional signatures of non-small-cell lung cancer, finding enrichment in immune response and purinergic signaling in females.

Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies

This study performs a functional meta-analysis of transcriptomic studies to identify sex-based differences in biological mechanisms associated with alcohol use disorder.

Mechanistic models of signaling pathways deconvolute the functional landscape of glioblastoma at single cell resolution

This paper uses mechanistic signaling pathway models to analyze single-cell RNA-seq data from glioblastoma, revealing functional heterogeneity and drug resistance mechanisms at the single-cell level.

Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models

The paper introduces Metabolizer, a web tool that uses gene expression data to analyze metabolic pathway activities and predict therapeutic targets for disease treatment.

Signaling Pathway Activities Improve Prognosis for Breast Cancer

This study shows that signaling pathway activities are better predictors of breast cancer prognosis than gene-level features and identify additional genes contributing to prognosis beyond pathway analysis.