Vanja Tepavčević

The paper analyzes single-cell data from multiple sclerosis patients to identify sex-specific molecular differences in brain and immune cells across disease progression.

This study identifies consistent sex differences in gut microbiota of MS patients across multiple cohorts, highlighting the importance of sex as a variable in microbiome research.

This study shows that astrocyte CB1R signaling promotes inflammation in MS by disrupting the blood-brain barrier and reducing BBB function.

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

This study shows that IRF5 regulates microglial myelin clearance and cholesterol metabolism after demyelination, with implications for remyelination in multiple sclerosis.

This study shows that genetically-modified macrophages can deliver Sema3F to demyelinating lesions, increasing OPC recruitment and accelerating remyelination in mice.

This study shows baclofen, a GABABR agonist, promotes remyelination in mouse models of demyelination, suggesting it could be a therapeutic for multiple sclerosis.