Haruhiko Siomi

The paper analyzes transposable elements in Parkinson Disease datasets to build a cell-type specific atlas and explore their role in sex differences.

This study identifies REFEE as a post-transcriptional regulator of repetitive RNAs that influences zygotic genome activation in mouse embryos.

The paper identifies Obox4 as a redundant transcription factor that promotes zygotic genome activation in mouse embryos, compensating for the loss of Dux.

This study shows that TDP-43 prevents L1 retrotransposition in mouse embryos and stem cells, protecting genome integrity.

The paper shows Mod(mdg4)-N variants repress HeT-A retrotransposons by blocking subtelomeric enhancers in Drosophila ovarian cells, leading to female sterility.

This study shows that MERVL RNA is essential for proper regulation of the host transcriptome and chromatin state during early mouse embryo development, with knockdown causing embryonic lethality.

This study shows that PIWI genes and piRNAs are essential for producing functional oocytes in golden hamsters, with different effects on gene expression and DNA methylation depending on the PIWI gene.

This study investigates piRNA size variations and PIWI protein dynamics during hamster oocyte maturation, revealing stage-specific piRNA binding and transcriptional regulation in ovarian piRNA clusters.

The paper identifies Nxf2 as a key component in the Piwi-piRNA pathway, showing it forms complexes that stabilize Piwi and Panx and initiate co-transcriptional silencing of target transcripts.