Alicia Amadoz

This study identifies sin-lncRNA, a long non-coding RNA that regulates mitochondrial metabolism during cellular senescence by modulating oxidative phosphorylation and DLST localization.

The paper presents a large-scale cancer pharmacogenomic screen with 11,576 experiments on 910 drug combinations across 85 cancer cell lines, enabling crowd-sourced prediction of synergistic drug pairs and biomarkers.

The paper introduces Metabolizer, a web tool that uses gene expression data to analyze metabolic pathway activities and predict therapeutic targets for disease treatment.

This study shows that signaling pathway activities are better predictors of breast cancer prognosis than gene-level features and identify additional genes contributing to prognosis beyond pathway analysis.

This paper introduces a method to estimate cell functional activities from gene expression and mutations, showing its utility in disease mechanisms and clinical outcome prediction across 5640 cancer patients.