UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation
Kayla J. Fasano, Anna E. Yoshida, Jane Madden, Kelsey E. Mauk, Lin Wei Tung, Thomas H. Edwards, Donna M. Shows, Caroline Stefani, David G. Kugler, Sheila Scheiding, Adarsh B. Manjunath, Megan E. Smithmyer, Oliver J. Harrison, Cate Speake, James D. Lord, Adam Lacy‐Hulbert
This study shows UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation, disrupt epithelial homeostasis, and increase susceptibility to intestinal inflammation.
bioRxiv · Mar 16, 2026 · PreprintImmunology