Author

Megan E. Smithmyer

Benaroya Research InstituteORCID 0000-0002-1005-0621Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

CATE SPEAKEiD· 3 shared Jane Hoyt BuckneriD· 2 shared Abigail TwoyiD· 1 shared Adam K. SavageiD· 1 shared Adam Lacy‐HulbertiD· 1 shared Adarsh B. Manjunath· 1 shared Aishwarya ChanderiD· 1 shared Alexander T. HeubeckiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

CATE SPEAKEORCID

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Author profile →

4 papers

Recent·Most cited

Heterogeneity of HCMV-Specific CD8+ T Cells is Established Early in Infection, Clonally Encoded, and Stable Over Time

Samuel D. Klebanoff, Matthew F. Lawrance, Kimberly O’Brien, Megan E. Smithmyer, Cate Speak, Amy Susan Codd, Emily S. Ford, David M. Koelle, Jane Hoyt Buckner, Evan William Newell, Daniel Campbell

The paper tracks CMV-specific CD8+ T cells over time to show that clonal diversity and phenotypes are established early and remain stable during chronic infection.

bioRxiv · Oct 16, 2026 · PreprintImmunology

Soluble LAG-3 Identifies a Dynamic Early T Cell Activation Window in self-reactivity, Type 1 Diabetes, and Broader Immune Responses.

Saptarshi Roy, Megan Lynn Proffer, Farooq Syed, Megan E. Smithmyer, Anup R. Sharma, Abigail Twoy, Emily Soohoo, Jyoti Rana, Jason M. Spaeth, Everett H. Meyer, Kent P. Jensen, CATE SPEAKE, William Hagopian, Jon D. Piganelli

This study identifies soluble LAG-3 (sLAG-3) as an early biomarker of T cell activation in type 1 diabetes, detectable before islet autoantibody development and associated with beta-cell stress and high-risk HLA genotypes.

bioRxiv · Apr 2, 2026 · PreprintImmunology

UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation

Kayla J. Fasano, Anna E. Yoshida, Jane Madden, Kelsey E. Mauk, Lin Wei Tung, Thomas H. Edwards, Donna M. Shows, Caroline Stefani, David G. Kugler, Sheila Scheiding, Adarsh B. Manjunath, Megan E. Smithmyer, Oliver J. Harrison, Cate Speake, James D. Lord, Adam Lacy‐Hulbert

This study shows UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation, disrupt epithelial homeostasis, and increase susceptibility to intestinal inflammation.

bioRxiv · Mar 16, 2026 · PreprintImmunology

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy Adults

Qiuyu Gong, Mehul Sharma, Marla C. Glass, Emma Lo Kuan, Aishwarya Chander, Mansi Singh, Lucas T. Graybuck, Zachary Thomson, Christian M. LaFrance, Samir Rachid Zaim, Tao Peng, Lauren Y. Okada, Palak C. Genge, Katherine E. Henderson, Elisabeth M. Dornisch, , Claire E. Gustafson

This study uses multi-omic profiling to analyze immune cell dynamics in healthy adults over time, finding age-related transcriptional changes in T cells and impaired memory B cell responses in older adults.

Nature · Oct 29, 2025Peer-reviewedImmunology